Synthesis, Characterization And Antibacterial studies of some Azomethine and Azo- Compound Derivatives of selected Sulfa Drugs

International Journal of Applied Chemistry

© 2020 by SSRG - IJAC Journal

Volume 7 Issue 2

Year of Publication : 2020

Authors : Haider Husine Abd-Ali ,Bushra K. Al-Salami and Mohammed Ahmed Abd

10.14445/23939133/IJAC-V7I2P106

How to Cite?

Haider Husine Abd-Ali ,Bushra K. Al-Salami and Mohammed Ahmed Abd, "Synthesis, Characterization And Antibacterial studies of some Azomethine and Azo- Compound Derivatives of selected Sulfa Drugs," SSRG International Journal of Applied Chemistry, vol. 7,  no. 2, pp. 32-47, 2020. Crossref, https://doi.org/10.14445/23939133/IJAC-V7I2P106

Abstract:

Three series of compounds have been synthesized, the first series included preparation of Schiff-bases ( NC1-NC4) by condensation reaction of Salicylaldehyde with a select species of Sulfa drugs like , Sulfanilamide, Sulfadiazine , Sulfamerazine and Sulfathiazole . The second series included preparation of azo compounds (Azo1 , Azo2 , Azo3and Azo4) Which contains aldehyde group via converting Sulfathiazol, Sulfadiazine and Sulfanilamide to dizonium salt followed by coupling reaction with 2-hydroxy benzaldehyde in alkaline medium . The third series includes synthesis of azo Schiff bases (CH1-CH8) in excellent yield via condensation of different sulfa drugs and ethylene diamine . The structures of synthesized compound have been characterized by spectroscopic methods such as infrared , 1H-NMR and mass spectra . The purity of compound and evaluation of Rf value were determined by TLC. The above mentioned compound were studied in vitro for their antimicrobial activity against Staphylococcus aureus , Escherichia coli and fungicidal activity against Candida albicans and Aspergillusniges Also the antioxidant of some compounds have been Calculated .

Keywords:

azo, azo-Schiff base,Schiff bases, sulfa drugs, 2-hydroxybenzaldehyde

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