Urticaria Multiforme: 2 Case Reports and Literature Review

International Journal of Medical Science

© 2026 by SSRG - IJMS Journal

Volume 13 Issue 1

Year of Publication : 2026

Authors : Diana Ly-Liu, Ana Andreu, Ellen O´Riordan, Domingo Ly-Pen

10.14445/23939117/IJMS-V13I1P102

How to Cite?

Diana Ly-Liu, Ana Andreu, Ellen O´Riordan, Domingo Ly-Pen, "Urticaria Multiforme: 2 Case Reports and Literature Review," SSRG International Journal of Medical Science, vol. 13,  no. 1, pp. 11-14, 2026. Crossref, https://doi.org/10.14445/23939117/IJMS-V13I1P102

Abstract:

Introduction: Urticaria Multiforme is a self-limited, benign dermatological disease, mainly in children (usually between 4 months and 6 years old), that can be and that should be diagnosed in a primary care setting. Case report: Two cases of Urticaria Multiforme, a very specific skin rash, almost pathognomonic, are presented. The general condition of the child is excellent; the lesions can be itchy and may have some flu-like symptoms. Usually, there are no other systemic symptoms. Laboratory tests are not helpful in Urticaria Multiforme diagnosis. Conclusion: General practitioners can accurately diagnose Urticaria Multiforme based on the clinical history and physical examination. This will avoid emergency departments overloading, family stress, and unnecessary tests.

Keywords:

Urticaria Multiforme.

References:

[1] Diana Ly-Liu et al., “A Very Frightening But Not Dangerous Rash in Children,” Irish Medical Journal, vol. 118, no. 1, pp. 1-6, 2025.
[Google Scholar] [Publisher Link]
[2] Jason J. Emer et al., “Urticaria Multiforme,” The Journal of Clinical and Aesthetic Dermatology, vol. 6, no. 3, pp. 34-39, 2013.
[Google Scholar] [Publisher Link]
[3] Maria Claudia Alves Luce et al., “Urticaria Multiforme: A Case Report in an Infant,” Brazilian Annals of Dermatology, vol. 94, no. 5, pp. 628-630, 2019.
[CrossRef] [Google Scholar] [Publisher Link]
[4] L. Sempau et al., “Urticaria Multiforme: A Report of 5 Cases and a Review of the Literatura,” Actas Dermo-Sifiliográficas, vol. 107, no. 1, pp. e1-e5, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[5] Mariana Barros et al., “Urticaria Multiforme: A Benign Frightening Rash,” BMJ Case Reports, vol. 14, pp. 1-2, 2021.
[CrossRef] [Google Scholar] [Publisher Link]
[6] Danielle M. Jones, Adrianna E. Sosa, Vini Vijayan, “Urticaria Multiforme,” The Journal od Pediatrics, vol. 257, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[7] Lourds Tamayo-Sanchez, Ramon Ruiz-Maldonado, and Amelia Laterza, “Acute Annular Urticaria in Infants and Children,“ Pediatric Dermatology, vol. 14, pp. 231-234, 1997.
[CrossRef] [Google Scholar] [Publisher Link]