The Synthesis of Optically-Active erythro- Methylphenidate by Diastereoselective Hydrogenation Using Ru-BINAP Complex Catalyst

International Journal of Applied Chemistry

© 2020 by SSRG - IJAC Journal

Volume 7 Issue 2

Year of Publication : 2020

Authors : Yoshifumi Yuasa, Akiko Horizoe

10.14445/23939133/IJAC-V7I2P110

How to Cite?

Yoshifumi Yuasa, Akiko Horizoe, "The Synthesis of Optically-Active erythro- Methylphenidate by Diastereoselective Hydrogenation Using Ru-BINAP Complex Catalyst," SSRG International Journal of Applied Chemistry, vol. 7,  no. 2, pp. 70-74, 2020. Crossref, https://doi.org/10.14445/23939133/IJAC-V7I2P110

Abstract:

Optically-active erythro-methylphenidate 1 has been synthesized from methyl 2-phenyl-2-(2’- piperidylidene)acetate 2 by diasteroselective hydrogenation using the Ru-BINAP complex catalyst as the key step. Piperidylidene acetate 2 was prepared by two routes either from 2,3,4,5-tetrahydro-6-methoxypyridine 4 or 5-Ncarbobenzyloxyamino-pentanoic acid 5.

Keywords:

Diasteroselective hydrogenation; methylphenidate, methyl 2-phenyl-2-(2’-piperidyl)-acetate, methyl 2-phenyl-2-(2’-piperidylidene)acetate, Ru-BINAP complex catalyst.

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