Antibacterial Effects and Synthesized New Derivatives of 4-hydroxy-chromen-2-one

International Journal of Applied Chemistry

© 2019 by SSRG - IJAC Journal

Volume 6 Issue 2

Year of Publication : 2019

Authors : Aziz Behrami

10.14445/23939133/IJAC-V6I2P108

How to Cite?

Aziz Behrami, "Antibacterial Effects and Synthesized New Derivatives of 4-hydroxy-chromen-2-one," SSRG International Journal of Applied Chemistry, vol. 6,  no. 2, pp. 50-52, 2019. Crossref, https://doi.org/10.14445/23939133/IJAC-V6I2P108

Abstract:

In present paper , we report the organic syntheses of three compounds from 4-hydroxychromen- 2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-Hydroxy-2-oxo-2H-chromene-3- sulfonic acid (4-methoxy-phenyl)-amide (a). N-[(4- Hydroxy-2-oxo-2H-chromen-3-yl)-(2-hydroxyphenyl)- methylene]-acetamide (b) , 4-Hydroxy-3-[(6- nitro-benzothiazol-2-ylimino)-methyl]-chromen-2-one (c), have been synthesized and characterized using melting points , IR spectra , 1H-NMR and 13C-NMR spectra. The antibacterial activity of synthesized compounds and streptomycin and cephalexin at concentrations of 2mg/ml, 3mg/ml and 5mg/ml , have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E.coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity

Keywords:

Coumarine derivatives, antibacterial activity, FTIR-Spectroscopy, NMR.

References:

[1] Lee.S.H , Shin, D.S, Kim.J.S , K.-B. Oh and Kan.S.S, Arch. Pharm. Res, 2003; (26).
[2] Vyas.K.B, NimavatK.S, Jani.G.R, and Hathi.M.V, Orbital, 2009; 1, (183).
[3] Abyshev.A.V, GimdeinV.A, SemenovE.V, E.MAgevE.M, Abdulla A.A, Zade and Gueseinov, Pharm.Chem.J., 2006; 40.(607).
[4] Aytemir.M.D , Hider.R.C , Erol.D.D,Ozalp.M and Ekizoglu.M, Turk.J.chem., 2003; 27 : (445).
[5] El.Saghier.M.M,Naili.M.B,Rammash.M.Kh,Saleh.N.H and Kreddan.K.M, Arkivoc, 2007;(83).
[6] Nofa.Z.M ,El-Zahar.M and Abd El Karim.M ,Molecules, 2000; 5: (99).
[7] Chaluvaraju .KC and Ishwarbhat , K.Asian ,J Chem 2008; 20, (4335).
[8] Ra Kali.R , S,Grworamma.J , and Suresh.B, Asian J Chem 2008: 20: (5289).
[9] Mohammed Ashraf.A and Mohammed.SH . Boorg Med Chem. Lett 2009; 17: (3314).
[10] Nofal .ZM, El-Zahar .M, Abd El-Karim .S, Novel coumarin derivatives with expected biological activity, Molecules. 2000; 5: (99- 113).
[11] Vyas .KB, Nimavat. KS, Jani .GR, Hathi. MV, Synthesis and microbial activity of coumarin derivatives metal complex: An in vitro evaluation.Orbital, 2009; 1: (183-192).
[12] A. A. Abou-Hussein, Wolfgang Linert, Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 141, 15 April 2015, Pages 223-23.
[13] Danijela Lj Stojković, Verica V. Jevtić, Nenad Vuković, Milena Vukić, Srećko R. Trifunović, Synthesis, characterization, antimicrobial and antitumor reactivity of new palladium(II) complexes with methionine and tryptophane coumarine derivatives. Journal of Molecular Structure, Volume 1157, 5 April