Research Article | Open Access | Download PDF
Volume 13 | Issue 6 | Year 2026 | Article Id. IJECE-V13I6P105 | DOI : https://doi.org/10.14445/23488549/IJECE-V13I6P105Ulcerative Colitis Detection and Severity Prediction Using a Hybrid Deep Learning Model
SumedhVithalrao Dhole, Chetan S. More, Anuradha Sagar Nigade, Sonali Kishore Pawar, A.Y. Prabhakar, Sangeeta Rajendra Chougule
| Received | Revised | Accepted | Published |
|---|---|---|---|
| 07 Mar 2026 | 06 Apr 2026 | 05 May 2026 | 27 Jun 2026 |
Citation :
SumedhVithalrao Dhole, Chetan S. More, Anuradha Sagar Nigade, Sonali Kishore Pawar, A.Y. Prabhakar, Sangeeta Rajendra Chougule, "Ulcerative Colitis Detection and Severity Prediction Using a Hybrid Deep Learning Model," International Journal of Electronics and Communication Engineering, vol. 13, no. 6, pp. 50-64, 2026. Crossref, https://doi.org/10.14445/23488549/IJECE-V13I6P105
Abstract
Ulcerative Colitis Detection and Severity Prediction research creates an effective and dependable automated model to identify the severity of colon diseases using Wireless Capsule Endoscopy (WCE) images. Current methods typically use single deep learning models or conventional machine learning models, which do not readily model both fine-grained variations in mucosal texture and global contextual interactions, particularly when applied to small medical data sets. The improvements of generalization were done by data augmentation and training of the model (categorical cross-entropy loss) with optimized hyperparameters. It was applied to the Python platform with the deep learning libraries and tested on the WCE Curated Colon Disease Dataset, comprising 800 images and four severity levels. The suggested method had a precision of 97.5, which is a better performance than the current models. This system has advantages because it offers accurate diagnosis with computer-assisted assistance to gastroenterologists and aids in the early and accurate evaluation of the severity of UC. The proposed model uniquely combines- Local convolutional features via ResNet-50, Global contextual features via Vision Transformer, and Handcrafted clinical texture descriptors (GLCM + LBP). This multi-source feature fusion is reduced via PCA to preserve 95% variance and addresses the core limitations of single-architecture models that tend to either underfit local texture patterns or miss long-range spatial dependencies.
Keywords
Ulcerative Colitis, ResNet-50, Vision Transformer, Colonoscopy Image Classification, Deep Learning.
References
- Marek Vebr et al., “A Narrative Review of Cytokine Networks: Pathophysiological and Therapeutic Implications for Inflammatory Bowel Disease Pathogenesis,” Biomedicines, vol. 11, no. 12, pp. 1-52, 2023.
[CrossRef] [Google Scholar] [Publisher Link] - Chan Hyung Lee et al., “Animal Models of Inflammatory Bowel Disease: Novel Experiments for Revealing Pathogenesis of Colitis, Fibrosis, and Colitis-Associated Colon Cancer,” Intestinal Research, vol. 21, no. 3, pp. 295-305, 2023.
[CrossRef] [Google Scholar] [Publisher Link] - Christian Philipp Selinger, Konstantina Rosiou, and Marco V. Lenti, “Biological Therapy for Inflammatory Bowel Disease: Cyclical Rather than Lifelong Treatment?,” BMJ Open Gastroenterology, vol. 11, no. 1, pp. 1-6, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Catherine Le Berre, Silvio Danese, and Laurent Peyrin-Biroulet, “Can We Change the Natural Course of Inflammatory Bowel Disease,” Therapeutic Advances in Gastroenterology, vol. 16, pp. 1-19, 2023.
[CrossRef] [Google Scholar] [Publisher Link] - Samina Khan et al., “Factors Influencing the Quality of Life in Inflammatory Bowel Disease: A Comprehensive Review,” Disease-a-Month, vol. 70, no. 1, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Rasmus Rankala et al., “Costs of Medications Used to Treat Inflammatory Bowel Disease,” Scandinavian Journal of Gastroenterology, vol. 59, no. 1, pp. 34-38, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Ryan Ungaro et al., “A Treat-to-Target Update in Ulcerative Colitis: A Systematic Review,” The American Journal of Gastroenterology, vol. 114, no. 6, pp. 874-883, 2019.
[CrossRef] [Google Scholar] [Publisher Link] - Asif Hassan Syed et al., “Advances in Inflammatory Bowel Disease Diagnostics: Machine Learning and Genomic Profiling Reveal Key Biomarkers for Early Detection,” Diagnostics, vol. 14, no. 11, pp. 1-26, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Iolanda Valentina Popa et al., “A Machine Learning Model Accurately Predicts Ulcerative Colitis Activity at One Year in Patients Treated with Anti-Tumour Necrosis Factor α Agents,” Medicina, vol. 56, no. 11, pp. 1-9, 2020.
[CrossRef] [Google Scholar] [Publisher Link] - Claudia Diaconu et al., “The Role of Artificial Intelligence in Monitoring Inflammatory Bowel Disease-The Future Is Now,” Diagnostics, vol. 13, no. 4, pp. 1-13, 2023.
[CrossRef] [Google Scholar] [Publisher Link] - Hassaan Malik et al., “Multi-Classification Deep Learning Models for Detection of Ulcerative Colitis, Polyps, and Dyed-Lifted Polyps Using Wireless Capsule Endoscopy Images,” Complex & Intelligent Systems, vol. 10, pp. 2477-2497, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Amit Das et al., “Deep Learning for Classification of Inflammatory Bowel Disease Activity in Whole Slide Images of Colonic Histopathology,” The American Journal of Pathology, vol. 195, no. 4, pp. 680-689, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - Venkat Margapuri, “Diagnosis and Severity Assessment of Ulcerative Colitis Using Self Supervised Learning,” 2025 IEEE Symposium on Computational Intelligence in Health and Medicine Companion (CIHM Companion), Trondheim, Norway, pp. 1-5, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - Sabrina Gloria Giulia Testoni et al., “Artificial Intelligence in Inflammatory Bowel Disease Endoscopy,” Diagnostics, vol. 15, no. 7, pp. 1-44, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - Jaehyuk Lee, and Eunchan Kim, “Multi-Task Deep Learning Framework for Enhancing Mayo Endoscopic Score Classification in Ulcerative Colitis,” Digital Health, vol. 11, pp. 1-11, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - Zeynep Özdemir, Hacer Yalim Keles, and Ömer Özgür Tanriöver, “CLoE: Curriculum Learning on Endoscopic Images for Robust MES Classification,” IEEE Access, vol. 14, pp. 30441-30454, 2026.
[CrossRef] [Google Scholar] [Publisher Link] - Mehwish Ahmed, Molly L. Stone, and Ryan W. Stidham, “Artificial Intelligence and IBD: Where are We Now and Where Will We Be in the Future?,” Current Gastroenterology Reports, vol. 26, pp. 137-144, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Gian Eugenio Tontini et al., “Artificial Intelligence in Gastrointestinal Endoscopy for Inflammatory Bowel Disease: A Systematic Review and New Horizons,” Therapeutic Advances in Gastroenterology, vol. 14, pp. 1-16, 2021.
[CrossRef] [Google Scholar] [Publisher Link] - Ryan W. Stidham et al., “Artificial Intelligence-Enabled Clinical Trials in Inflammatory Bowel Disease: Automating and Enhancing Disease Assessment and Study Management,” Gastroenterology, vol. 169, no. 3, pp. 432-443, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - Pieter Sinonquel et al., “Artificial Intelligence and its Impact on Quality Improvement in Upper and Lower Gastrointestinal Endoscopy,” Digestive Endoscopy, vol. 33, no. 2, pp. 242-253, 2021.
[CrossRef] [Google Scholar] [Publisher Link] - Jacob Broder Brodersen et al., “Artificial Intelligence-assisted Analysis of Pan-enteric Capsule Endoscopy in Patients with Suspected Crohn's Disease: A Study on Diagnostic Performance,” Journal of Crohn’s and Colitis, vol. 18, no. 1, pp. 75-81, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Gary R. Lichtenstein et al., “Increased Lifetime Risk of Intestinal Complications and Extraintestinal Manifestations in Crohn’s Disease and Ulcerative Colitis,” Gastroenterology & Hepatology, vol. 18, no. 1, pp. 32-43, 2022.
[Google Scholar] [Publisher Link] - Vipul Jairath et al., “Novel Outcomes in Inflammatory Bowel Disease,” Journal of Crohn’s and Colitis, vol. 19, no. 4, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - WCE Curated Colon Disease Dataset Deep Learning, Kaggle, 2025. [Online]. Available: https://www.kaggle.com/datasets/francismon/curated-colon-dataset-for-deep-learning
- Kaiming He et al., “Deep Residual Learning for Image Recognition,” 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), Las Vegas, NV, USA, pp. 770-778, 2016.
[CrossRef] [Google Scholar] [Publisher Link] - Haijig Sun et al., “An Improved Medical Image Classification Algorithm Based on Adam Optimizer,” Mathematics, vol. 12, no. 16, pp. 1-14, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Stefania Barburiceanu, Romulus Terebes, and Serban Meza, “3D Texture Feature Extraction and Classification using GLCM and LBP-based Descriptors,” Applied Sciences, vol. 11, no. 5, pp. 1-25, 2021.
[CrossRef] [Google Scholar] [Publisher Link] - Yann LeCun, Yoshua Bengio, and Geoffrey Hinton, “Deep Learning,” Nature, vol. 521, pp. 436-444, 2015.
[CrossRef] [Google Scholar] [Publisher Link] - Ian Goodfellow, Yoshua Bengio, and Aaron Courville, Deep Learning, MIT Press, 2016.
- [Google Scholar] [Publisher Link]
- Reed T. Sutton et al., “Artificial Intelligence Enabled Automated Diagnosis and Grading of Ulcerative Colitis Endoscopy Images,” Scientific Reports, vol. 12, pp. 1-10, 2022.
[CrossRef] [Google Scholar] [Publisher Link] - Syed Abdullah Shah et al., “A Hybrid Approach of Vision Transformers and CNNs for Detection of Ulcerative Colitis,” Scientific Reports, vol. 14, pp. 1-16, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Vinay Jahagirdar et al., “Diagnostic Accuracy of Convolutional Neural Network Based Machine Learning Algorithms in Endoscopic Severity Prediction of Ulcerative Colitis: A Systematic Review & Meta-Analysis,” Gastrointestinal Endoscopy, vol. 98, no. 2, pp. 145-154, 2023.
[CrossRef] [Google Scholar] [Publisher Link] - Md. Nasim Ahmed et al., “A Triple Pronged Approach for Ulcerative Colitis Severity Classification using Multimodal, Meta, and Transformer Based Learning,” Scientific Reports, vol. 15, pp. 1-15, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - Boying Nie, and Gaofeng Zhang, “Ulcerative Severity Estimation Based on Advanced CNN-Transformer Hybrid Models,” Applied Sciences, vol. 15, no. 13, pp. 1-15, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - Venkat Margapuri, “Diagnosis and Severity Assessment of Ulcerative Colitis Using Self Supervised Learning,” 2025 IEEE Symposium on Computational Intelligence in Health and Medicine Companion (CIHM Companion), Trondheim, Norway, pp. 1-5, 2025.
[CrossRef] [Google Scholar] [Publisher Link] - Yuanming Yang et al., “Biomarkers Prediction and Immune Landscape in Ulcerative Colitis: Findings based on Bioinformatics and Machine Learning,” Computers in Biology and Medicine, vol. 168, pp. 1-16, 2024.
[CrossRef] [Google Scholar] [Publisher Link] - Zhengxuan Qiu et al., “VIGIL: Vision-Language Guided Multiple Instance Learning Framework for Ulcerative Colitis Histological Healing Prediction,” arXiv preprint, pp. 1-12, 2025.
[CrossRef] [Google Scholar] [Publisher Link]