Clinico-Histopathological Correlation in Leprosy: At M.Y. Hospital Indore
|International Journal of Medical Science|
|© 2019 by SSRG - IJMS Journal|
|Volume 6 Issue 7|
|Year of Publication : 2019|
|Authors : Shikha Ghanghoria,Arvind Ghanghoria ,Sonal Meshram|
How to Cite?
Shikha Ghanghoria,Arvind Ghanghoria ,Sonal Meshram, "Clinico-Histopathological Correlation in Leprosy: At M.Y. Hospital Indore," SSRG International Journal of Medical Science, vol. 6, no. 7, pp. 14-19, 2019. Crossref, https://doi.org/10.14445/23939117/IJMS-V6I7P103
Leprosy is a chronic infectious disease of skin and peripheral nerves has been classified by multiple authorities, like Madrid classification(1953), WHO classification (1982), Indian classification and Ridley Jopling classification of which most widely accepted is Ridley and Jopling classification in 1966.They classified leprosy on the basis of clinical, histopathological, immunological and bacteriological parameters in to LL( lepromatous leprosy), BL( borderline leprosy), BB( mid borderline), BT( borderline tuberculoid),TT( tuberculoid) is a continous spectrum with frequent transformation of one form in to another. Study aims at clinic-histopathological correlation in leprosy which would helps to predict the course, outcome and complications of the disease.Material & Methods: The present study was conducted in the Department of Pathology, M.G.M. Medical College, Indore on 100 patients. All the clinically diagnosed and suspected patients of leprosy during a period of 2015 to 2018 were enrolled in the study .Results: Total 100 patients were studied, out of which 66 were males and 34 were females. On clinical evaluation BT was diagnosed in 52%, TT in 33% ,BLin 6%, in IL 4% , LLin 2% and not specified in 1% patients. On histopathological evalution, epidermal changes seen in 47% and dermal changes like granuloma formation seen in 40 % ,dermal infiltration in 20%, adnexal infiltration in 8%, nerve infiltration in 7%, adnexal with nerve infiltration in 10%, perivascular with adnexal infiltration in 9% and non specific cases in 1% ,therefore BT(35%) was the most common histopathological diagnosis after that TT(30%)followed by BL(3%),LL(2%) and BB (1%).Conclusion :When we correlate this study we found that maximumclinico histopathological correlation was noted in LL(100%), TT(90.9%), BT(67.30%) and least correlation seen with BB(50%) and BL (50%).
Leprosy, Histopathology, Ridley Jopling.
 Tan SY, Graham C. Armauer Hansen (1841-1912): discoverer of the cause of leprosy. Singapore Med J 2008; 49: 520-521.
 Singh A, Gaur R, Ambey R. Spectrum of leprosy patients with clinicohistopathologicalcorrelation : a hospital based study. Asian Journal of Medical Science, Volume-4(2013).
 Announcement: India achieves national elimination of leprosy. Indian J Lepr 2006; 78: 101.
 Global leprosy strategy 2016–2020: accelerating towards a leprosy-free world. New Delhi, World Health Organization, Regional Office for South-East Asia, 2016. Available at: http:// www.wpro.who.int/leprosy/documents/globalleprosystrategy2016-2020.pdf, accessed August 2016.  Weekly Epidemiological Record No. 35. 2017 Sep 1;92:501–20.
 Lockwood DN,Sarno E and Smith WC (2007).Classifying leprosy patients searching for the perfect solution?Lepr Rev.78:317-320
 Ridley DS, Charles SK. The pathology of leprosy, In: Leprosy (Hastings). Churchill Livingstone. 1985.pp. 111
 Pandya AN, Tailor HJ: Clinicopathological correlation of leprosy. Indian J Dermatol VenereolLeprol. 2008; 74:174-6.
 Moorthy BN, Kumar P, Chatura KR, Chandrasekhar HR, Basavaraja PK: Histopathological correlation of skin
biopsies in leprosy. Indian J Dermatol VenereolLeprol. 2001;67:299-301.
 Kar PK, Arora PN: Clinicopathological study of macular lesions in leprosy. Indian J Lepr. 1994;66:435-41.
 Jerath VP, Desai SR: Diversities in clinical and histopathological classification of Leprosy. Lepr India. 1982;54:30.
 Bhatia AS, Katoch K, Narayanan RB, Ramu G, Mukherjee A, Lavania RK: Clinical and histopathological correlation in the classification of leprosy. Int J Lepr. 1993;61:433-8.
 Jha R, Karki S: Limitations of clinic-histopathological Correlation of Skin biopsies In Leprosy. J Nepal health Res Counc. 2010;8:40-3.
 Sharma A, Sharma RK, Goswsami KC, Bardwaj S. Clinico-Histopathological Correlation in Leprosy. JK Science 2008;10(3):120-123