Diagnostic Value of Hemogram Parameters as a Biomarker in Infection and Sepsis

International Journal of Medical Science
© 2020 by SSRG - IJMS Journal
Volume 7 Issue 5
Year of Publication : 2020
Authors : I Putu A. Santosa, Dian Luminto, Anik Widijanti, Catur S. Sutrisnani, Hani Susianti
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I Putu A. Santosa, Dian Luminto, Anik Widijanti, Catur S. Sutrisnani, Hani Susianti, "Diagnostic Value of Hemogram Parameters as a Biomarker in Infection and Sepsis," SSRG International Journal of Medical Science, vol. 7,  no. 5, pp. 22-26, 2020. Crossref, https://doi.org/10.14445/23939117/IJMS-V7I5P106

Abstract:

Red Cell Distribution Width (RDW), Platelet Distribution Width (PDW), Mean Platelet Volume (MPV), and Neutrophil-Lymphocyte Count Ratio (NLCR) are part of hemogram parameters in Complete Blood Count which inexpensive and easy to obtain, but their clinical usefulness in sepsis management is controversial. We conducted a cross-sectional study where RDW, PDW, MPV, and NLCR rates were evaluated on 64 sepsis patients, 30 patients with infection, and 71 control at Central Laboratory of Dr. Saiful Anwar Hospital. Statistically significant difference was found between 3 groups in all parameters. Both RDW and NLCR showed an area under curve (AUC) values over 0.90 in differentiating healthy group to a patient with infection. For sepsis, RDW (AUC 0.91, sensitivity 86.7%, specificity 80.3%) and NLCR (AUC 0.979, sensitivity 93.3% specificity 97.2%) showed a similar accuracy. Median PDW was higher in the sepsis patient (p<0.001) and patient with infection (p=0.078). Median MPV was significantly different in the infection group (p<0.05), but not significant in patients with sepsis (p=0.464). Our study shows RDW and NLCR have good diagnostic values; therefore it could be promising markers in predicting infection and sepsis. 

Keywords:

Red Cell Distribution Width, Platelet Distribution Width, Mean Platelet Volume, Neutrophil-Lymphocyte Count Ratio, sepsis

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