Models of Graded Closed Craniocerebral Injury in Rats

International Journal of Medical Science

© 2015 by SSRG - IJMS Journal

Volume 2 Issue 5

Year of Publication : 2015

Authors : Wei Wang and Weiming Zheng

10.14445/23939117/IJMS-V2I5P103

How to Cite?

Wei Wang and Weiming Zheng, "Models of Graded Closed Craniocerebral Injury in Rats," SSRG International Journal of Medical Science, vol. 2,  no. 5, pp. 8-11, 2015. Crossref, https://doi.org/10.14445/23939117/IJMS-V2I5P103

Abstract:

To build closed traumatic brain injury models in varying degrees with high accuracy, repeatability as well as easy operation, We use lateral fluid percussion method to simulate the rats’ three types of closed traumatic brain injury models in slight, moderate and serious degrees after 24 hours and valuate the situations of neurological deficit of the rats in each group through NSS, then conduct quantitative measurement of brain water content as well as blood brain barrier at the same time, finding that the more serious the rat’s traumatic brain injury degree is, the higher NSS scores shows, and the more serious damage brain water content as well as blood brain barrier possess, the differences of which have statistical significance (P<0.05).So we have built a traumatic brain injury model in varying degrees with high stability and easy operation, which lays the foundation for the preliminary study of traumatic brain injury to a certain extent

Keywords:

Trauma brain injury, Model Brain water content, Blood brain barrier, Lateral fluid percussion

References:

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