Prognostic Biomarkers For Mortality In Severe COVID-19 Patients : The Worth of C-reactive Protein, Serum Ferritin and D-dimer

International Journal of Medical Science

© 2021 by SSRG - IJMS Journal

Volume 8 Issue 8

Year of Publication : 2021

Authors : Kripasindhu Gantait, Arindam Bhattacharjee, Rabi Lochan Maji, Akshaya Elango

10.14445/23939117/IJMS-V8I8P103

How to Cite?

Kripasindhu Gantait, Arindam Bhattacharjee, Rabi Lochan Maji, Akshaya Elango, "Prognostic Biomarkers For Mortality In Severe COVID-19 Patients : The Worth of C-reactive Protein, Serum Ferritin and D-dimer," SSRG International Journal of Medical Science, vol. 8,  no. 8, pp. 15-18, 2021. Crossref, https://doi.org/10.14445/23939117/IJMS-V8I8P103

Abstract:

Background: Nealy 4.5 million deaths of Coronavirus disease- 19 (COVID-19) have been accounted for worldwide since December 2019. We plan to look through risk factors related to death in COVID-19 patients and determine the utility of the D-dimer, ferritin, and C-reactive protein(CRP) as biomarkers for disease severity and clinical outcome.
Methods: We retrospectively investigated the clinical characteristics, laboratory findings and mortality- related risk factors of 81 patients of COVID-19 in the High Dependency Unit(HDU) of Midnapore Medical College, West Bengal, India. The relationship of the D-dimer, ferritin and the CRP between patients with the survivor group and the death group was investigated. SPSS version 28 was employed for statistical analysis and a P-value < 0.05 was considered statistically significant.
Results: The mean age of the 38 discharged patients and 43 death patients were 40.35±12.98 and 56.34±13.91 years respectively, and the mean age was significantly increased with the death group(p<0.0001). The mean D-dimer of the survivor group and the death group was 1301.67 ± 1123.54 and 3839.03±1188.07 respectively and the mean D-dimer was significantly increased with the death group (p<0.0001). CRP and ferritin were likewise altogether significantly present in the death group (p< 0.0001).
Conclusion: D-dimer, ferritin, and CRP are usually raised in patients with COVID-19 and could be effectively accessible and cost-effective biomarkers of mortality in the serious COVID-19 patients of HDU.

Keywords:

D-dimer, CRP, Ferritin, Corona virus disease-19, Biomarker, Mortality

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