Left Ventricular Dysfunction In Patients With Liver Disease

International Journal of Medical Science
© 2021 by SSRG - IJMS Journal
Volume 8 Issue 10
Year of Publication : 2021
Authors : Kamal Dwebeh, Abdullah Cheikh Ibrahim, Maher Madi
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How to Cite?

Kamal Dwebeh, Abdullah Cheikh Ibrahim, Maher Madi, "Left Ventricular Dysfunction In Patients With Liver Disease," SSRG International Journal of Medical Science, vol. 8,  no. 10, pp. 1-5, 2021. Crossref, https://doi.org/10.14445/23939117/IJMS-V8I10P101

Abstract:

A. Background: Both liver and heart diseases are considered a serious problem in the health system and a major reason for the deterioration of the quality of life and its short expected duration. Therefore, it is important to study the hepato-cardiac interactions.

B. Aim & Objective: studying the effects of liver diseases on left ventricle (LV) systolic, diastolic & electrophysiological functions.

C. Material & Methods: A total of 63 cases of diagnosed liver disease patients (22 without cirrhosis and 41 with cirrhosis) with 63 age sex-matched healthy control subjects were included in this study. Both those with liver disease and healthy subjects underwent an electrocardiogram and 2D Echocardiography.

D. Results: QTc interval in liver disease patients was longer than controls and abnormally prolonged in cirrhotic patients. The systolic function of LV in liver disease patients was mostly normal but increased in cirrhotic patients with a statistical significance when compared to non-cirrhotic patients and the control group. Diastolic dysfunction was noticed in cirrhotic and non-cirrhotic patients. In cirrhosis, there were a statistically significant increase in IVRT [ 92.36±12.2 ms] VS.[ 73.7±10.2 ms] in the control group (P<0.05). In noncirrhotic patients, there was a statistically significant increase in IVRT [88.77±13.1] VS. [73.7±10.2] in the control group (P<0.05). We noticed a statistically significant increase in Myocardial Performance Index(MPI) in cirrhotic and non-cirrhotic patients [0.43±0.1 and 0.39±0.05 respectively] VS. [0.33±0.04] in the control group (P<0.05).

E. Conclusion: In patients with liver disease, QTc interval was longer, and in addition to compromised LV diastolic function, MPI was also increased, which reflects both systolic and diastolic LV dysfunction.

Keywords:

liver disease; cirrhosis; Left Ventricular function; Doppler Echocardiography.

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