The Prevalence of Depression in People with Rheumatoid Arthritis

International Journal of Medical Science
© 2023 by SSRG - IJMS Journal
Volume 10 Issue 1
Year of Publication : 2023
Authors : Yousif Mufaz Myhydeen
pdf
How to Cite?

Yousif Mufaz Myhydeen, "The Prevalence of Depression in People with Rheumatoid Arthritis," SSRG International Journal of Medical Science, vol. 10,  no. 1, pp. 25-30, 2023. Crossref, https://doi.org/10.14445/23939117/IJMS-V10I1P105

Abstract:

Inflammation of the joints and other body systems are hallmarks of rheumatoid arthritis (R.A.), a chronic autoimmune inflammatory disease. It has been suggested in the recent literature that R.A. may be linked to depression. In R.A., depression is more common than in the general population. It has been associated with more pain and fatigue, worse quality of life in terms of health, more significant physical disability, and higher medical costs. Patients with Rheumatoid Arthritis who are depressed have worse long-term outcomes, including tremendous pain and mortality. So, therapies for depression that attempt to boost patients' perceptions of their health and well-being might be pretty effective. The purpose of this study is to use the Patient Health Questionnaire-9 (PHQ-9) to determine the prevalence of depression among patients with a confirmed diagnosis of rheumatoid arthritis, as well as to examine its relationship with disease activity and to compare it to that seen in the general population. A case-control study with 50 consecutive patients diagnosed with R.A. according to the ACR/EULAR diagnostic criteria for Rheumatoid Arthritis and 50 healthy controls. Questionnaires and in-depth interviews were used to compile the data. Subjects disclosed their ages, sexes, socioeconomic statuses, illness diagnoses, disease durations, quality of life, and medicines Using the DSM-IV criteria; depression was measured using the PHQ-9. The clinical Disease Activity Index was used to evaluate disease prevalence (CDAI). Patients had a mean age of 47.3 12.8 years old, while controls were 38.1 14.2 years old. For every 50 patients, 39 were diagnosed with depression, whereas only 22 of the controls did so. Patients with Rheumatoid Arthritis had a significantly higher rate of major depression than the control group. Patients with Rheumatoid Arthritis showed a strong correlation between depression severity and disease activity. Rheumatoid arthritis patients were shown to have a higher-than-average rate of depression, which was linked to worse disease outcomes. These findings indicate the need for depression screening and treatment as part of effective R.A. therapy.

Keywords:

Prevalence, Depression, People, Rheumatoid, Arthritis.

References:

[1] Jeffery RC. Clinical features of rheumatoid arthritis. Medicine (Baltimore) 2014;42:231–6.
[2] Firestein GS et al., Etiology and Pathogenesis of Rheumatoid Arthritis. Kelley and Firestein's Textbook of Rheumatology, 10th edition, Elsevier, 2017.
[3] Kyla A McKay et al., “Psychiatric Comorbidity is Associated with Disability Progression in multiple sclerosis,” Neurology, vol. 90, no. 15, pp. 1316-1323, 2018. Crossref, https://doi.org/10.1212/WNL.0000000000005302
[4] Kojima Masayo et al., “Depression, Inflammation, and Pain in Patients with Rheumatoid Arthritis,” Arthritis Care & Research, vol. 61, no. 8, pp. 1018-1024, 2009. Crossref, https://doi.org/10.1002/art.24647
[5] Rinie Geenen et al., “Psychological Interventions for Patients with Rheumatic Diseases and Anxiety Or Depression,” Best practice & Clinical research rheumatology, vol. 26, no. 3, pp. 305-319, 2012. Crossref, https://doi.org/10.1016/j.berh.2012.05.004
[6] Brygida Kwiatkowska et al., “Factors of Depression Among Patients with Rheumatoid Arthritis,” Reumatologia, vol. 56, no. 4, pp. 219- 227, 2018. Crossref, https://doi.org/10.5114/reum.2018.77973
[7] E Yelin, “Work Disability in Rheumatoid Arthritis: Effects of The Disease, Social, and Work Factors,” Annals of Internal Medicine, vol. 93, no. 4, pp. 551-556, 1980. Crossref, https://doi.org/10.7326/0003-4819-93-4-551
[8] Anthony S. Fauci, Carol A. Langford, Rheumatoid Arthritis. Harrison's Rheumatology, 4th edition. McGraw-Hill Education, 2017.
[9] O’Dell JR et al., Rheumatoid Arthritis.Current Diagnosis and Treatment Rheumatology, 3rd Edition, The McGraw-Hill Education, 2013.
[10] Francesca Angelotti, “One year in review 2017: Pathogenesis of Rheumatoid Arthritis,” Clinical and Experimental Rheumatology, vol. 35, no. 3, pp. 368-378, 2017.
[11] jinpiao Lin et al., “Datasets of YY1 Expression in Rheumatoid Arthritis Patients,” Data in Brief, vol. 9, pp. 1034-1038, 2016. Crossref, https://doi.org/10.1016/j.dib.2016.11.046
[12] Lee Goldman, and Andrew I. Schafer, Goldman-Cecil medicine, Elsevier, vol. 2, 26th Edition, 2020.
[13] Ralston SH, McInnes IB., Davidson's Principles and Practice of Medicine, Rheumatology and bone disease, 22nd edition Elsevier Churchill Livingstone. 2014.
[14] Cynthia S. Crowson et al., The Lifetime Risk of Adult‐Onset Rheumatoid Arthritis and Other Inflammatory Autoimmune Rheumatic Diseases,” Arthritis & Rheumatism, vol. 63, no. 3, pp. 633-639, 2011. Crossref, https://doi.org/10.1002/art.30155
[15] Daniel Aletaha et al., “2010 Rheumatoid Arthritis Classification Criteria: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative,” Arthritis & Rheumatism, vol. 62, no. 9, pp. 2569-2581, 2010. Crossref, https://doi.org/10.1002/art.27584
[16] Lucas Francisco Botequio Mella, Manoel Barros Bértolo, and Paulo Dalgalarrondo, “Depressive symptoms in Rheumatoid Arthritis,” Brazilian Journal of Psychiatry, vol.32 no.3, pp. 257-263, 2010. Crossref, https://doi.org/10.1590/s1516-44462010005000021
[17] K Kroenke, RL Spitzer, and J B Williams, “The PHQ‐9: Validity of a Brief Depression Severity Measure,” Journal of general Internal Medicine, vol. 16, no. 9, pp. 606-613, 2001. Crossref, https://doi.org/10.1046/j.1525-1497.2001.016009606.x
[18] D Aletaha, and J Smolen, “The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in Rheumatoid Arthritis,” Clinical and experimental Rheumatology, vol. 23, no. 5, pp. 100-108, 2005.
[19] Wendlassida Joelle Tiendrébéogo Zabsonre et al., “Frequency and Factors Associated with Depression in Rheumatoid Arthritis in African Black Patients: Case Control Study,” Open Journal of Rheumatology and Autoimmune Diseases, vol. 9, no. 2, pp. 35-41, 2019. Crossref, https://doi.org/10.4236/ojra.2019.92004
[20] Xin Fu et al., “The Prevalence of Depression in Rheumatoid Arthritis in China: A Systematic Review,” Oncotarget, vol. 8, no. 32, pp. 53623-53630, 2017. Crossref, https://doi.org/10.18632/oncotarget.17323
[21] Ahmad-Reza Jamshidi et al., “Anxiety and Depression in Rheumatoid Arthritis: An Epidemiologic Survey and Investigation of Clinical Correlate in Iranian Population,” Rheumatology International, vol. 36, no. 8, pp. 1119-1125, 2016. Crossref, https://doi.org/10.1007/s00296-016-3493-4
[22] Olga J G Schiepers, Marieke C Wichers, and Michael Maes, “Cytokines and Major Depression,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 29, no. 2, pp. 201-17. Crossref, https://doi.org/10.1016/j.pnpbp.2004.11.003
[23] Kenneth R Kaufman, “Etanercept, Anticytokines, and Mania,” International clinical psychopharmacology, vol. 20, no. 4, pp. 239-41, 2005. Crossref, https://doi.org/10.1097/00004850-200507000-00008
[24] Kai G Kahl et al., “Cortisol, the Cortisol-Dehydroepiandrosterone Ratio, and Proinflammatory Cytokines in Patients with Current Major Depressive Disorder Comorbid with A Borderline Personality Disorder,” Biological Psychiatry, vol. 59, no. 7, pp. 667-671, 2006. Crossref, https://doi.org/10.1016/j.biopsych.2005.08.001
[25] David B Weiss et al., "Psychiatric Manifestations of Autoimmune Disorders," Current treatment options in neurology, vol. 7, no. 5, pp. 413-417, 2005.
[26] Anisman Hymie et al., “Cytokines as a Precipitant of Depressive Illness: Animal and Human Studies,” Current pharmaceutical design, vol. 11, no. 8, pp. 963-972. 2005. Crossref, https://doi.org/10.2174/1381612053381701
[27] T. Pincus et al., “Prevalence of self-reported Depression in Patients with Rheumatoid Arthritis. Rheumatology,” The British Journal Of Rheumatology, vol. 35, no. 9, pp. 879-83, 1996. Crossref, https://doi.org/10.1093/rheumatology/35.9.879
[28] Owais Kareem et al., “Frequency of Depression in Patients with Rheumatoid Arthritis,” The Professional Medical Journal, vol. 27, no. 3, pp. 646-650, 2020. Crossref, https://doi.org/10.29309/TPMJ/2020.27.03.4242
[29] Christian Adrián López-Castillo et al., “Impact of Educational Level on Rheumatoid Arthritis: A Systematic Review,” Reista Colombiana Rheumatologia, vol. 21, no. 4, pp. 201–212, 2014. Crossref, https://doi.org/10.1016/j.rcreu.2014.09.002
[30] Brygida Kwiatkowska et al., “Factors of Depression Among Patients with Rheumatoid Arthritis,” Reumatologia, vol. 56, no. 4, pp. 219- 227, 2018, Crossref, https://doi.org/10.5114/reum.2018.77973