Study of the Effect of Diabetes Mellitus Type II on Spirometry Test among Adults

International Journal of Medical Science

© 2023 by SSRG - IJMS Journal

Volume 10 Issue 5

Year of Publication : 2023

Authors : Afraa Moussa, Mohammed Al-khayer, Ruba Salman

10.14445/23939117/IJMS-V10I5P107

How to Cite?

Afraa Moussa, Mohammed Al-khayer, Ruba Salman, "Study of the Effect of Diabetes Mellitus Type II on Spirometry Test among Adults," SSRG International Journal of Medical Science, vol. 10,  no. 5, pp. 46-50, 2023. Crossref, https://doi.org/10.14445/23939117/IJMS-V10I5P107

Abstract:

Type 2 Diabetes Mellitus (T2DM) presents a significant concern in the realm of public health, contributing to heightened morbidity due to its widespread impact on multiple bodily systems, including adverse effects on lung function. The primary objective of this investigation was to delve into the intricacies of lung function among individuals afflicted by T2DM. Furthermore, we aimed to elucidate the connection between the severity of the disease and lung function. To accomplish this, an in-depth analytical case-control study spanned one year, from 2022 to 2023, at Tishreen University Hospital in Lattakia, Syria. Our research involved a cohort of T2DM patients aged 18 years and older, with a minimum disease duration of two years (referred to as cases), who were meticulously compared to a well-matched group of healthy individuals (referred to as controls) regarding their lung functions. Results: There were no significant differences between the two groups regarding age, sex, and body mass index BMI(p>0.05). Duration of diabetes was longer than 10 years in 35.7% of the patients, with the presence of uncontrolled disease in 60.7% and 70.8% according to HbA1C and fasting blood glucose levels, respectively. A statistically significant decrease in FEV1 and FVC was seen in T2DM patients compared to healthy controls (p:0.0001) without a significant decrease in FEV1/FVC(p:0.6). There was a significant decrease in FEV1(p:0.01) and FVC(p:0.003) with increasing duration of disease without significant alterations in FEV1/FVC(p:0.08). In addition, there was a significant decrease in FEV1 and FVC (p<0.05) in uncontrolled patients according to HbA1C and fasting blood glucose.

Keywords:

Glycemic control, Pulmonary functions, Restrictive, Type 2 diabetes mellitus, FEV1.

References:

[1] Abdulfatai B. Olokoba, Olusegun A. Obateru, and Lateefat B. Olokoba, “Type 2 Diabetes Mellitus: A Review of Current Trends,” Oman Medical Journal, vol. 27, no. 4, pp. 269-273, 2012.
[CrossRef] [Google Scholar] [Publisher Link]
[2] Jay S. Skyler et al., “Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis,” American Diabetes Association, vol. 66, no. 2, pp. 241-255, 2017.
[CrossRef] [Google Scholar] [Publisher Link]
[3] “2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022,” Diabetes Care, American Diabetes Association, vol. 43, pp. 14-31, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[4] Ralph A. DeFronzo et al., “Type 2 Diabetes Mellitus,” Nature Reviews Disease Primers, vol. 1, 2015.
[CrossRef] [Google Scholar] [Publisher Link]
[5] Anthony S. Fauci et al., Harrison's Principles of Internal Medicine, 19th ed., New York: McGraw-Hill, vol. 2, no. 16, pp. 3178-3209, 2015.
[Google Scholar] [Publisher Link]
[6] Philippe A. Halban et al., “B-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment,” The Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 6, pp. 1983-1992, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[7] Sudesna Chatterjee, Kamlesh Khunti, and Melanie J. Davies, “Type 2 Diabetes,” The Lancet, vol. 389, pp. 2239-2251, 2017.
[CrossRef] [Google Scholar] [Publisher Link]
[8] Jitendra Padhye, V. Firoiu, and Don Towsley, “A Stochastic Model of TCP Reno Congestion Avoidance and Control,” University of Massachusetts, Technical Report, 1999.
[Google Scholar] [Publisher Link]
[9] Francesco Paneni et al., “Diabetes and Vascular Disease: Pathophysiology, Clinical Consequences, and Medical Therapy,” European Heart Journal, vol. 34, no. 31, pp. 2436-2443, 2013.
[CrossRef] [Google Scholar] [Publisher Link]
[10] Jessica L. Harding et al., “Global Trends in Diabetes Complications: A Review of Current Evidence,” Diabetologia, vol. 62, pp. 3-16, 2019.
[CrossRef] [Google Scholar] [Publisher Link]
[11] Brian L. Graham et al., “Standardization of Spirometry 2019 Update, An Official American Thoracic Society and European Respiratory Society Technical Statement,” American Journal of Respiratory and Critical Care Medicine, vol. 200, no. 8, pp. 70-88, 2019.
[CrossRef] [Google Scholar] [Publisher Link]
[12] Sanja Stanojevic et al., “ERS/ATS Technical Standard on Interpretive Strategies for Routine Lung Function Tests,” European Respiratory Journal, vol. 60, pp. 1-32, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[13] Martin R. Miller et al., “Standardisation of Spirometry,” European Respiratory Journal, vol. 26, pp. 319-338, 2005.
[CrossRef] [Google Scholar] [Publisher Link]
[14] Minaxi Saini et al., “Pulmonary Pathology among Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis,” Current Diabetes Reviews, vol. 16, no. 7, pp. 759-769, 2020.
[CrossRef] [Google Scholar] [Publisher Link]
[15] Mario Cazzola et al., “High Glucose Enhances Responsiveness of Human Airways Smooth Muscle via the Rho/ROCK Pathway,” American Journal of Respiratory Cell and Molecular Biology, vol. 47, no. 4, pp. 509-516, 2012.
[CrossRef] [Google Scholar] [Publisher Link]
[16] Samantha F. Ehrlich et al., “Patients Diagnosed with Diabetes are at Increased Risk for Asthma, Chronic Obstructive Pulmonary Disease, Pulmonary Fibrosis, and Pneumonia but Not Lung Cancer,” Diabetes Care, vol. 33, no. 1, pp. 55-60, 2010.
[CrossRef] [Google Scholar] [Publisher Link]
[17] G. Shravya Keerthi, “Role of Duration of Diabetes on Ventilator Capacities and Expiratory Flow Rate in Type 2 Diabetes Mellitus,” Biology Agriculture and Healthcare, vol. 2, no. 6, pp. 77-83, 2012.
[Google Scholar] [Publisher Link]
[18] Stefan Kopf et al., “Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes Related Feature in Patients with Type 2 Diabetes,” Respiration, vol. 96, no. 1, pp. 29-40, 2018.
[CrossRef] [Google Scholar] [Publisher Link]
[19] Saeed Kolahian, Veronika Leiss, and Bernd Nürnberg, “Diabetic Lung Disease: Fact or Fiction?,” Reviews in Endocrine and Metabolic Disorders, vol. 20, pp. 303-319, 2019.
[CrossRef] [Google Scholar] [Publisher Link]
[20] Hans-Joachim Kabitz et al., “Diabetic Polyneuropathy is Associated with Respiratory Muscle Impairment in Type 2 Diabetes,” Diabetologia, vol. 51, pp. 191-197, 2018.
[CrossRef] [Google Scholar] [Publisher Link]
[21] Oana L. Klein et al., “Type II Diabetes Mellitus is Associated with Decreased Measures of Lung Function in a Clinical Setting,” Respiratory Medicine, vol. 105, no. 7, pp. 1095-1098, 2011.
[CrossRef] [Google Scholar] [Publisher Link]
[22] I. Amal Abd El-Azeem et al., “Pulmonary Function Changes in Diabetic Lung,” Egyptian Journal of Chest Diseases and Tuberculosis, vol. 62, no. 3, pp. 513-517, 2013.
[CrossRef] [Google Scholar] [Publisher Link]
[23] Swati H. Shah et al., “Pulmonary Function Tests in Type 2 Diabetes Mellitus and Their Association with Glycemic Control and Duration of the Disease,” Lung India, vol. 30, no. 2, pp. 108-112, 2013.
[CrossRef] [Google Scholar] [Publisher Link]
[24] H. Huang et al., “Effects of Type 2 Diabetes Mellitus on Pulmonary Function,” Experimental and Clinical Endocrinology and Diabetes, vol. 122, no. 6, pp. 322-326, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[25] Navkaran Shergill, and Ashok Kumar, “A Study of Pulmonary Functions in Punjabi Type 2 Diabetics and Non-Diabetics,” Journal of Exercise Science and Physiotherapy, vol. 13, no. 2, pp. 60-64, 2017.
[CrossRef] [Google Scholar] [Publisher Link]
[26] Ismail Okur et al., “The Effects of Type 2 Diabetes Mellitus and its Complications on Physical and Pulmonary Functions: A Case-Control Study,” Physiotherapy Theory and Practice, vol. 36, no. 8, pp. 916-922, 2020.
[CrossRef] [Google Scholar] [Publisher Link]