Study of serum levels of Homocysteine, Vitamin B12 and Folic acid in women with a previous history of Gestational Diabetes Mellitus

International Journal of Medical Science

© 2016 by SSRG - IJMS Journal

Volume 3 Issue 4

Year of Publication : 2016

Authors : Dr. Y. Ramananda Singh, Nagraj Soni, Dr. G. G. Kaushik, Dr. Sonali Sharma and Dr. J S Broca

10.14445/23939117/IJMS-V3I4P101

How to Cite?

Dr. Y. Ramananda Singh, Nagraj Soni, Dr. G. G. Kaushik, Dr. Sonali Sharma and Dr. J S Broca, "Study of serum levels of Homocysteine, Vitamin B12 and Folic acid in women with a previous history of Gestational Diabetes Mellitus," SSRG International Journal of Medical Science, vol. 3,  no. 4, pp. 1-4, 2016. Crossref, https://doi.org/10.14445/23939117/IJMS-V3I4P101

Abstract:

Background: Gestational Diabetes mellitus (GDM) is a common condition seen during the 24th to 28th week of pregnancy which resolves spontaneously with the birth of the baby. In the present study we have studied the serum levels of homocysteine (Hcy), vitamin B12 and folic acid in women with the history of GDM and tried to highlight the correlation especially of homocysteine with GDM. Materials and Methods: The present study was conducted on 100 women with GDM patients attending the Gynaecology & Obstetrics OPD, J.L.N. Medical College & Associated groups of Hospital, Ajmer. The results of patients were compared with 100 women without GDM subjects. Anthropometric measurements and biochemical estimations were performed, after taking approval from ethical committee. Results: The mean serum levels of homocysteine, vitamin B12, folic acid, fasting glucose and fasting insulin were elevated in women with GDM as compared to women without GDM (control) subjects. Serum Hcy, fasting glucose and fasting insulin were observed statistically significant in subjects studied when compared with controls. Conclusion: In women with a previous history of GDM a statistically significant rise in the serum levels of homocysteine, fasting glucose, fasting insulin, HOMA IR, total cholesterol, triglycerides, LDL cholesterol and VLDL cholesterol was seen. Further deeper studies into the matter need to be carried out to bring out the importance of using homocysteine level as a marker of impending diabetes in women who have had an earlier pregnancy with GDM

Keywords:

Gestational Diabetes Mellitus, Homocysteine, Vitamin B12, Folic acid, Insulin, HOMA IR, Lipid Profile.

References:

[1] Ural SH, Gilmartin AB1, Repke JT. Gestational diabetes mellitus. Rev Obstet Gynecol. Summer 2008;1(3):129-34
[2] V Seshiah, V Balaji, Madhuri S Balaji, CB Sanjeevi, A Gree. Gestational Diabetes Mellitus in India. JAPI . September; 2004:VOL 52
[3] Stuebe AM, Mantzoros C, Kleinman K, Gillman MW, Rifas- Shiman S, Seely EW, Rich Edwards J. Gestational glucose tolerance and maternal metabolic profile at 3 years postpartum. Obstet Gynecol.2011 Nov;118(5):1065-73.
[4] Jacobson DW: Homocysteine and vitamins in cardiovascular diseases. Clin. Chem. 1998; 44: 1833-1843
[5] Arpita P. Patel, Chandan Chakrabarti , Arjun Singh, Jatin D Patel, Hitesh A.Mewada, S.L.Sharma: Effect of Homocysteine ,Vitamin B12 , Folic acid during pregnancy. NHL Journal of Medical Sciences. July 2012;Vol. 1:Issue1 [6] Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228–237.
[7] Mason JB, Miller JW. The effects of vitamins B12, B6, and folate on blood homocysteine levels. Ann NY Acad Sci .1992; 669:197–203
[8] Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH: Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem. 1993 Sep;39(9):1764-79
[9] Stein Emil Vollset,Helga Refsum, Lorentz M Irgens, Barbro Mork Emblem,Aage Tverdal, Håkon K Gjessing,Anne Lise Bjørke Monsen, andPer Magne Ueland. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study. Am J Clin Nutr .April 2000 ;71 :962-968
[10] J S Kaplan, S Iqbal, B G England, C M Zawacki and W H Herman. Is pregnancy in diabetic women associated with folate deficiency?. Diabetes Care .July 1999 vol. 22no. 7 1017-1021
[11] Lopez Quesada et al, 2003]. Lopez-Quesada E, Vilaseca MA, Artuch R, Gomez E, Lailla JM. Homocysteine and other plasma amino acids in preeclampsia and in pregnancies without complications. Clin Biochem.2003; 36(3):185-92
[12] Tarim E., T.Bagls, E.Kilicdag, S. Erkanli, E. Aslan, N. Sezgin and E.Kuksu: Eleveted plasma homocysteine levels in gestational diabetes mellitus. Acta. Obstet. Gynecol. Scand, 2004;83;543-547.
[13] Hague WM. Homocysteine and pregnancy. Best Pract Res Clin Obstet Gynaecol .2003; 17(3);459-469.
[14] De Fronzo RA, Abdul Ghani MAJ. Preservation of β cell function: the key to diabetes prevention. Clin Endoccrinol Metab. 2011, 96(8):2354-2366.
[15] Wajchenberg BL. β cell failure in diabetes and preservation by clinical treatment. Endocr Rev .2007; 28((2):187-218.
[16] Bonora E, Saggiani F, Targher G et al. Homeostasis Model Assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diab care .2000; 23:23-25.
[17] Guven MA, Kilinc M, Batukan C, Ekerbicer HC, Aksu T. Elevated second trimester serum homocysteine levels in women with gestational diabetes mellitus. Arch Gynecol Obstet . 2006; 274:333-337.
[18]Tarim E, Yigit F, Kilicdag E et al. Early onset of subclinical atherosclerosis in women with gestational diabetes mellitus. Ultrasound Obstet Gynecol .2006;27(2):177-182.