A Clinical Study on Patients Presenting with Thyroid Swelling and Its Correlation with TFT, USG, FNAC and Anti TPO Antibodies

International Journal of Medical Science

© 2016 by SSRG - IJMS Journal

Volume 3 Issue 10

Year of Publication : 2016

Authors : Hanushraj. R, Sudharsan.S, Balasubramaniyan. S and Pradeep Kumar. M

10.14445/23939117/IJMS-V3I10P101

How to Cite?

Hanushraj. R, Sudharsan.S, Balasubramaniyan. S and Pradeep Kumar. M, "A Clinical Study on Patients Presenting with Thyroid Swelling and Its Correlation with TFT, USG, FNAC and Anti TPO Antibodies," SSRG International Journal of Medical Science, vol. 3,  no. 10, pp. 1-8, 2016. Crossref, https://doi.org/10.14445/23939117/IJMS-V3I10P101

Abstract:

Objective: The aim was to study the clinical presentation of patients with thyroid swelling and to correlate thyroid function test (freeT3, freeT4, TSH), USG thyroid, FNAC and Anti TPO Antibodies. Design: Cross-Sectional study. Materials and methods: 30 patients with age above 13 years who presented to our outpatient department with complaints of thyroid swelling who are not under treatment were included in our study. Symptoms regarding hypothyroidism or hyperthyroidism were noted followed by Anti TPO antibody titer, free T3, free T4, TSH, USG thyroid and FNAC were performed. Results: In our study 77% (n=23) were females and 23% (n=7) were males. Most of our study population belongs to the age group of 31-50yrs (n=16). 36.67% (n=11) had neither of hypo or hyperthyroid features and 36.67% (n=11) had features of hypothyroidism. TFT showed predominance of euthyroid state in 40% (n=12) of our study population followed by hypothyroidism in 26.67% (n=8) of study population. Anti TPO titer was raised in 53.33% (n=16) of patients. Colloid goiter was the most common finding in FNAC 30% (n=9), maliganacy was noted in 2 patients (6.66%). Similarly features of colloid goiter was noted in 56.67% (n=17) of patients with USG thyroid. There were no correlations found between TSH levels and anti TPO titer.

Keywords:

Thyroid swelling, goiter, FNAC, USG, TFT, Anti TPO antibodies.

References:

[1]hlomo Melmed (2011).“Williams Text Book Of Endocrinology” 13th Edition. Philadelphia, Elsevier.
[2] Kenneth MF, Strieder T, Wiersinga WM (2004). The environment and    autoimmune thyroid diseases. Eur J Endocrinol; 150(5):605-18.
[3] Ghaib H, Goeliner JR. Fine neelde aspiration biopsy of the thyroid: An appraisal. Ann Intern Med 1993; 118: 282-9. PMid:8420446.
[4] Nelson JC, Wilcox RB. Analytical performance of free and total thyroxine assay, Clin Chem 1996; 42: 146-154. PMid:8565218.
[5] Bravemann LE. Evaluation of thyroid status in patients with thyrotoxocosis, Clin Chem 1996; 42: 174-181. PMid:8565222.
[6] Beever K, Bradbury J, Philips D, et al. Highly sensitive assays of auto antibodies to thyroglobulin and to thyroid peroxidase. Clin Chem 1989; 35: 1949-54. PMid:2776323.
[7] Kabelitz M, Liesenkotter KP, Stach B, et al. The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area, European Journal of Endocrinology (2003); 148 301-307. www.eje-online.org/content/148/3/301.full.pdf
[8] Tamai H, Uno H, Hirota Y. (2005). Immunogenetics of Hashimoto’s and Grave’s diseases. J. Clin. Endocrinology. Metab. 60: 62-65.
[9] Chandrakant S. Pandav, Kapil Yadav, et al (2013). Iodine deficiency disorders (IDD) control in India. Indian J Med Res 138, September 2013, pp 418-433. http://icmr.nic.in/ijmr/2013/september/0922.pdf 
[10] Sivaranjani H, Anna C. Das, Govindaiah H. K. Correlation between anti tpo antibodies and fnac in the diagnosis of hypothyroidism: an observational study. Journal of Evolution of Medical and Dental Sciences. 2015;4(65)11362-11366. http://www.jemds.com/data_pdf/1_sivaranjini%20%20%20kumGU.pdf 
[11] Vanderpump MPJ, Tunbridge WMG,  French JM, et al. The incidence of thyroid disorders in the    community: a twenty-year follow-up of the Whickham survey.Clin Endocrinol (Oxf) 1995; 43: 55-69. 
[12] Unnikrishnan AG, Menon UV. Thyroid disorders in India: An epidemiological perspective. Indian J Endo Meta 2015: 15; 78-81.