Electronic Cigarettes and DNA Damage

International Journal of Material Science and Engineering
© 2019 by SSRG - IJMSE Journal
Volume 5 Issue 3
Year of Publication : 2019
Authors : Thomas Prevenslik
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How to Cite?

Thomas Prevenslik, "Electronic Cigarettes and DNA Damage," SSRG International Journal of Material Science and Engineering, vol. 5,  no. 3, pp. 7-10, 2019. Crossref, https://doi.org/10.14445/23948884/IJMSE-V5I3P102

Abstract:

Electronic e-cigarettes are common throughout the world. E-cigarettes deliver the nicotine stimulant through aerosols to the lungs without burning tobacco. Recently, e-cigarette smokers have mysteriously expressed nicotine poisoning symptoms including nausea and vomiting, excessive salivation, headache, and dizziness followed by a period of central nervous system depression, paralysis, difficulty in breathing and even death. Unlike the immediacy of nicotine poisoning, the potential of cancer developing decades later from e-cigarette use was assessed with DNA tests that showed nicotine enhanced the UV-induced DNA mutation frequency in human lung and bladder epithelial cells by two- to fourfold. Enhanced DNA damage is consistent with simple QED that predicts nanoparticles (NPs) produced from the metal heater in the e-cigarette emit UV radiation well known to
cause DNA mutations that may lead to cancer. The mystery of nicotine poisoning is solved by removing the heater producing the NPs, but then the nicotine would remain in the ground state and not enhance the stimulation of the smoker's senses

Keywords:

e-cigarettes, nanoparticles, DNA damage, cancer.

References:

[1] (2019) The VOX website. [Online] "Vaping appears to be making hundreds of people sick. No one knows exactly why." Available: https://www.vox.com/science-and-health/2019/9/3/20847219/vaping-health-risks-2019-lung-damagedeath/
[2] M. Williams, A. Villarreal, K. Bozhilov, S. Lin, P. Talbot. "Metal and Silicate Particles Including Nanoparticles Are Present in Electronic Cigarette Cartomizer Fluid and Aerosol," PLOS vol. 8 pp. e57987, 2013.
[3] M. D. Wilson, K. A. Prasad, J. S. Kim, J. H. Park. "Characteristics of metallic nanoparticles emitted from heated Kanthal e-cigarette coils," Nanopart. Res: vol. 21, pp. 156, 2019.
[4] C. C. Harris. "Tobacco smoking, E-cigarettes, and nicotine harm," PNAS vol. 115, pp. 1406-1407, 2018.
[5] H. W. Lee, et al. "E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells," PNAS, pp. E1560–E1569, 2018.
[6] (2015-19) NanoQED website. [Online] "Simple QED Applications" Available: mamoqed.org.
[7] C. H. Rayburn, W. R. Harlan, H. R. Hanmer. "The Effect of Ultraviolet Radiation on Nicotine," J. Am. Chem. Soc. pp.
115-116. 1941.
[8] J. W. Young. et al. "Hydroxyl Radical Fluorescence and Quantum Yield Following Lyman‑ α Photoexcitation of Water Vapor in a Room Temperature Cell and Cooled in a Supersonic Expansion," J. Phys. Chem. A. 122:5602−5609, 2018.
[9] T. Prevenslik. "Cancer by UV radiation from nanoparticles
in GM food." Integr. Cancer Sci. Therap. 4(1): 2-4, 2017.
[10] P. M. Clayton, C. A. Vas, T. Bui, A. F. Drake, K. McAdam. "Spectroscopic Studies on Nicotine and Nornicotine in the UV Region," Chirality; vol. 25, pp. 288–293, 2013.
[11] G. K. Chandra, et al. "Probing in Vitro Ribose Induced DNA-Glycation Using Raman Microspectroscopy," Anal. Chem.; vol. 87, pp. 2655−2664, 2015.
[12] T. Prevenslik. "The Causal Link Between Vaccination Adjuvants and Autism," Inter. J. Research - Granthaalayah, vol. 7, pp. 288-295, 2019.
[13] T. Cheng. "Chemical evaluation of electronic cigarettes." Tob. Control. vol. 23, pp. ii11–ii17, 2014.
[14] W. D. van Dijk, S. Gopal, P. T. Scheepers. "Nanoparticles in cigarette smoke-real-time undiluted measurements by a scanning mobility particle sizer," Anal Bioanal Chem vol. 399, pp. 3573–3578, 2011.