An Analytical Cross-Sectional Study of the Effects of Hypoglycemia in Diabetic Patients

International Journal of Nursing and Health Science
© 2023 by SSRG - IJNHS Journal
Volume 9 Issue 1
Year of Publication : 2023
Authors : Yousif Mufaz Myhydeen
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Yousif Mufaz Myhydeen, "An Analytical Cross-Sectional Study of the Effects of Hypoglycemia in Diabetic Patients," SSRG International Journal of Nursing and Health Science, vol. 9,  no. 1, pp. 33-40, 2023. Crossref, https://doi.org/10.14445/24547484/IJNHS-V9I1P105

Abstract:

A significant public health concern is the rise in mortality and disease rates among individuals with diabetes mellitus. It is recognized that the circumstance contributes to bad health, high costs, and diminished productivity. We performed a cross-sectional study on 300 cases of individuals with two types of 1& 2 diabetes from the Mosul Region in Iraq to find and classify risk factors associated with more excellent rates of hypoglycemia. We confirm that the risk of hypoglycemia is increased by the prevalence of smoking and alcohol use, low BMI, an unhealthy diet, a lack of exercise, the absence of influenza and pneumococci vaccines, and the presence of other comorbidities like cardiovascular disease, thyroid disease, hyperlipidemia, retinopathy, and asthma. This contains publicly available information on the links between the prevalence of diabetes and human living. Furthermore, those with hypoglycemia were more likely to be undernourished, downhearted, impatient, and stressed. To sum up, knowing how diabetes works with other sociodemographic, environmental, or healthrelated risk factors can help find ways to regulate glucose more effectively and experience hypoglycemia less frequently. Our study may also lay the groundwork for changing existing safety services and bringing new ones to improve health by reducing hypoglycemic episodes in diabetic patients.

Keywords:

Hypoglycemia, Diabetic, Type 2 diabetes, Type1 diabetes.

References:

[1] Dragan Lovic et al., “The Growing Epidemic of Diabetes Mellitus,” Current Vascular Pharmacology, vol. 18, no. 2, pp. 104-109, 2020.
[CrossRef] [Google Scholar] [Publisher link]
[2] American Diabetes Association, “2. Classification and Diagnosis of Diabetes,” Diabetes Care, pp. S11-S24, 2017.
[CrossRef] [Google Scholar] [Publisher link]
[3] Nadia Lascar et al., “Type 2 Diabetes in Adolescents and Young Adults,” The Lancet Diabetes Endocrinology, vol. 6, no. 1, pp. 69-80, 2018.
[CrossRef] [Google Scholar] [Publisher link]
[4] Jessie N. Zurita-Cruz et al., “Health and Quality of Life Outcomes Impairment of Quality of Life in Type 2 Diabetes Mellitus: A Crosssectional Study,” Health and Quality of Life Outcomes, vol. 16, no. 1, 2018.
[CrossRef] [Google Scholar] [Publisher link]
[5] Paulien R. Wermeling et al., “Both Cardiovascular and Non-cardiovascular Comorbidity are Related to Health Status in Well-controlled Type 2 Diabetes Patients: A Cross-sectional Analysis,” Cardiovascular Diabetology, 2012.
[CrossRef] [Google Scholar] [Publisher link]
[6] Katharina Bannier et al., “Impact of Diabetes Mellitus and Its Complications: Survival and Quality-of-life in Critically Ill Patients,” Journal of Diabetes and Its Complications, vol. 29, no. 8, pp. 1130-1135, 2015.
[CrossRef] [Google Scholar] [Publisher link]
[7] Tapash Roy, and Cathy E. Lloyd, “Epidemiology of Depression and Diabetes: A Systematic Review,” Journal of Affective Disorders, 2012.
[CrossRef] [Google Scholar] [Publisher link]
[8] S.V. Bădescu et al., “The Association between Diabetes Mellitus and Depression,” Journal of Medicine and Life, vol. 9, no. 2, pp. 120- 125, 2016.
[Google Scholar] [Publisher link]
[9] Ahmed Iqbal, and Simon Heller, “Managing Hypoglycaemia,” Best Practice and Research. Clinical, Endocrinology Metabolism, vol. 30, no. 3, pp. 413-430, 2016.
[CrossRef] [Google Scholar] [Publisher link]
[10] Aysha Asif Sarwani et al., “Clinical Outcomes of Diabetic Ketoacidosis in Adult patients in Bahrain,” SSRG International Journal of Medical Science, vol. 8, no. 2, pp. 1-9, 2021.
[CrossRef] [Publisher link]
[11] Philip E. Cryer, Stephen N. Davis, and Harry Shamoon, “Hypoglycemia in Diabetes,” Diabetes Care, vol. 26, no. 6, pp. 1902–1912, 2003.
[CrossRef] [Google Scholar] [Publisher link]
[12] Janet K. Snell-Bergeon, and R. Paul Wadwa, “Hypoglycemia, Diabetes, and Cardiovascular Disease,” Diabetes Technology Therapeutics, S51-S58, 2012.
[CrossRef] [Google Scholar] [Publisher link]
[13] Benjamin M. Leon, and Thomas M. Maddox, “Diabetes and Cardiovascular Disease: Epidemiology, Biological Mechanisms, Treatment Recommendations and Future Research,” World Journal of Diabetes, vol. 6, no. 13, pp. 1246-1258, 2015.
[CrossRef] [Google Scholar] [Publisher link]
[14] International Hypoglycaemia Study Group, “Hypoglycaemia, Cardiovascular Disease, and Mortality in Diabetes: Epidemiology, Pathogenesis, and Management,” Lancet Diabetes and Endocrinology, vol. 7, no. 5, pp. 385-396, 2019.
[CrossRef] [Publisher link]
[15] Spyridon O. Bakatselos, “Hypoglycemia Unawareness,” Diabetes Research and Clinical Practice, vol. 93, pp. S92–S96, 2011.
[CrossRef] [Google Scholar] [Publisher link]
[16] Nicola N. Zammitt et al., “Modeling the Consistency of Hypoglycemic Symptoms: High Variability in Diabetes,” Diabetes Technology and Therapeutics, vol. 13, no. 5, pp. 571-578, 2011.
[CrossRef] [Google Scholar] [Publisher link]
[17] L. Diedrich, D. Sandoval, and S.N. Davis, “Hypoglycemia Associated Autonomic Failure,” Clin Auton Res., vol. 12, no. 5, pp. 358-365, 2002.
[18] Nicola N. Zammitt, and Brian M. Frier, “Hypoglycemia in Type 2 Diabetes: Pathophysiology, Frequency, and Effects of Different Treatment Modalities,” Diabetes Care, vol. 28, no. 12, pp. 2948–2961, 2005.
[CrossRef] [Google Scholar] [Publisher link]
[19] V. McAulay, I.J. Deary, and B.M. Frier, “Symptoms of Hypoglycaemia in People with Diabetes,” Diabetic Medicine: A Journal of the British Diabetic Association, vol. 18, no. 9, pp. 690-705, 2001.
[CrossRef] [Google Scholar] [Publisher link]
[20] Philip E. Cryer, “Diverse Causes of Hypoglycemia-associated Autonomic Failure in Diabetes,” The New England Journal of Medicine, vol. 350, no. 22, pp. 2272-2279, 2004.
[CrossRef] [Google Scholar] [Publisher link]
[21] P.E. Cryer, “Hypoglycemia Risk Reduction in Type 1 Diabetes,” Experimental and Clinical Endocrinology Diabetes, pp. S 412-S 423, 2001.
[CrossRef] [Google Scholar] [Publisher link]
[22] Stanford Patient Education Research Center, Stanford University School of Medicine. Diabetes: Sample Questionnaire; Stanford Patient Education Research Center, Stanford University School of Medicine: Stanford, CA, USA, 2012.
[23] DHHS, National Diabetes Statistics Report 2020, Centers for Disease Control and Prevention: Atlanta, GA, USA, vol. 2, 2020.
[24] Philip E. Cryer, “Hypoglycemia: Still the Limiting Factor in the Glycemic Management of Diabetes,” Endocrine Practice, vol. 14, no. 6, pp. 750-756, 2008.
[CrossRef] [Google Scholar] [Publisher link]
[25] Sophia Zoungas et al., “Severe Hypoglycemia and Risks of Vascular Events and Death,” The New England Journal of Medicine, vol. 363, no. 15, pp. 1410-1418, 2010.
[CrossRef] [Google Scholar] [Publisher link]
[26] Philip E. Cryer, Hypoglycemia in Diabetes: Pathophysiology, Prevalence, and Prevention, American Diabetes Association, 2016.
[Publisher link]
[27] Mazen Alsahli, and John E. Gerich, “Hypoglycemia in Patients with Diabetes and Renal Disease,” Journal of Clinical Medicine, vol. 4, no. 5, pp. 948-964, 2015.
[CrossRef] [Google Scholar] [Publisher link]
[28] Atsushi Goto et al., “Severe Hypoglycaemia and Cardiovascular Disease: Systematic Review and Meta-analysis with Bias Analysis,” BMJ, 2013.
[CrossRef] [Google Scholar] [Publisher link]
[29] Iciar Martín-Timón, and Francisco Javier Del Cañizo-Gómez, “Mechanisms of Hypoglycemia Unawareness and Implications in Diabetic Patients,” World Journal of Diabetes, vol. 6, no. 7, pp. 912–926, 2015.
[CrossRef] [Google Scholar] [Publisher link]
[30] Josefine E. Schopman, Jacqueline Geddes, and Brian M. Frier, “Prevalence of Impaired Awareness of Hypoglycaemia and Frequency of Hypoglycaemia in Insulin-treated Type 2 Diabetes,” Diabetes Research and Clinical Practice, vol. 87, no. 1, pp. 64-68, 2010.
[CrossRef] [Google Scholar] [Publisher link]
[31] J-S. Yun, et al., “Association between BMI and Risk of Severe Hypoglycaemia in Type 2 Diabetes,” Diabetes & Metabolism, vol. 45, no. 1, pp. 19-25, 2019.
[CrossRef] [Google Scholar] [Publisher link]
[32] Tsung-Cheng Tsai et al., “Body Mass Index–mortality Relationship in Severe Hypoglycemic Patients with Type 2 Diabetes,” The American Journal of the Medical Sciences, vol. 349, no. 3, pp. 192-198, 2015.
[CrossRef] [Google Scholar] [Publisher link]
[33] Kristina Norman et al., “Prognostic Impact of Disease-related Malnutrition,” Clinical Nutrition, vol. 27, no. 1, pp. 5-15, 2008.
[CrossRef] [Google Scholar] [Publisher link]
[34] Statista, How Much Time on Average Do You Spend on Your Phone on a Daily Basis?, 2022. [Online]. Available: https://www.statista.com/statistics/1224510/time-spent-per-day-on-smartphone-us/
[35] Melina A. Throuvala, et al., “The Role of Recreational Online Activities in School-based Screen time Sedentary Behaviour Interventions for Adolescents: A Systematic and Critical Literature Review,” International Journal of Mental Health and Addiction, vol. 19, pp. 1065-1115, 2021.
[CrossRef] [Google Scholar] [Publisher link]
[36] Anders Grøntved, and Frank B. Hu, “Television Viewing and Risk of Type 2 Diabetes, Cardiovascular Disease, and All-cause Mortality: A Meta-Analysis,” JAMA, vol. 305, no. 23, pp. 2448-2455, 2011.
[CrossRef] [Google Scholar] [Publisher link]
[37] World Health Organization, Obesity and Overweight, 2021. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
[38] Mary D. Adu et al., “Enablers and Barriers to Effective Diabetes Self-management: A Multi-national Investigation,” PLoS One, vol. 14, no. 6, 2019.
[CrossRef] [Google Scholar] [Publisher link]
[39] Morten Hasselstrom Jensen et al., “Smoking is Associated with Increased Risk of Not Achieving Glycemic Target, Increased Glycemic Variability, and Increased Risk of Hypoglycemia for People With Type 1 Diabetes,” Journal of Diabetes Science and Technology, vol. 15, no. 4, pp. 827-832, 2021.
[CrossRef] [Google Scholar] [Publisher link]
[40] T. Madhubala, R. Umagandhi, and P. Sathiamurthi, “Diabetes Prediction using Improved Artificial Neural Network using Multilayer Perceptron,” SSRG International Journal of Electrical and Electronics Engineering, vol. 9, no. 12, pp. 167-179, 2022.
[CrossRef] [Publisher link]
[41] Sang Ah Chang, “Smoking and Type 2 Diabetes Mellitus,” Diabetes & Metabolism Journal, vol. 36, no. 6, pp. 399-403, 2012.
[CrossRef] [Google Scholar] [Publisher link]
[42] Julie C. Will, et al., “Cigarette Smoking and Diabetes Mellitus: Evidence of a Positive Association from a Large Prospective Cohort Study,” International Journal of Epidemiology, vol. 30, no. 3, pp. 540-546, 2001.
[CrossRef] [Google Scholar] [Publisher link]
[43] Justin J. Sherman, “The Impact of Smoking and Quitting Smoking on Patients with Diabetes,” Diabetes Spectrum, vol. 18, no. 4, pp. 202-208, 2005.
[CrossRef] [Google Scholar] [Publisher link]
[44] Karen L. Whalen, and Robert D. Stewart, “Pharmacologic Management of Hypertension in Patients with Diabetes,” American Family Physician, vol. 78, no. 11, pp. 1277-1282, 2008.
[Google Scholar] [Publisher link]
[45] Paolo Severino, et al., “Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels,” International Journal of Molecular Sciences, vol. 19, no. 3, 2018.
[CrossRef] [Google Scholar] [Publisher link]
[46] Jun Duan et al., “Ultrasonography of Lower Limb Vascular Angiopathy and Plaque Formation in Type 2 Diabetes Patients and Finding Its Relevance to the Carotid Atherosclerotic Formation,” Pakistan Journal of Medical Sciences, vol. 30, no. 1, pp. 54-58, 2014.
[CrossRef] [Google Scholar] [Publisher link]
[47] Robert H. Nelson, “Hyperlipidemia as a Risk Factor for Cardiovascular Disease,” Primary Care, vol. 40, no. 1, pp. 195-211, 2013.
[CrossRef] [Google Scholar] [Publisher link]
[48] Barbara Idzior-Waluś, and Małgorzata Waluś-Miarka, “Treatment of Dyslipidemia in Diabetes—Individualization of Therapeutic Strategies,” Clinical Diabetology, vol. 2, no. 1, pp. 23-29, 2013.
[Google Scholar] [Publisher link]
[49] Myriam Ensling, William Steinmann, and Adam Whaley-Connell, “Hypoglycemia: A Possible Link between Insulin Resistance, Metabolic Dyslipidemia, and Heart and Kidney Disease (the Cardiorenal Syndrome),” Cardiorenal Medicine, vol. 1, no. 1, pp. 67-74, 2011.
[CrossRef] [Google Scholar] [Publisher link]
[50] Ahmadou M. Jingi et al., “Mechanism of Worsening Diabetic Retinopathy with Rapid Lowering of Blood Glucose: The Synergistic Hypothesis,” BMC Endocrine Disorders, vol. 17, 2017.
[CrossRef] [Google Scholar] [Publisher link]
[51] Workgroup on Hypoglycemia, American Diabetes Association, “Defining and Reporting Hypoglycemia in Diabetes: A Report from the American Diabetes Association Workgroup on Hypoglycemia,” Diabetes Care, vol. 28, no. 5, pp. 1245-1249, 2005.
[CrossRef] [Google Scholar] [Publisher link]
[52] Albert Van De Wiel, “Diabetes Mellitus and Alcohol,” Diabetes/Metabolism Research and Reviews, vol. 20, no. 4, pp. 263-267, 2004.
[CrossRef] [Google Scholar] [Publisher link]