Nano ZnO Loaded Trimethyl Chitosan Chloride (TMCC) - A Promising Nano Bio-composite for Antimicrobial and Wound Healing Cotton Fabric

International Journal of Polymer and Textile Engineering

© 2022 by SSRG - IJPTE Journal

Volume 9 Issue 1

Year of Publication : 2022

Authors : Firoz Ahmed, Md. Ibrahim H. Mondal, Md. Nazmul Huda, Md. Khademul Islam

10.14445/23942592/IJPTE-V9I1P102

How to Cite?

Firoz Ahmed, Md. Ibrahim H. Mondal, Md. Nazmul Huda, Md. Khademul Islam, "Nano ZnO Loaded Trimethyl Chitosan Chloride (TMCC) - A Promising Nano Bio-composite for Antimicrobial and Wound Healing Cotton Fabric," SSRG International Journal of Polymer and Textile Engineering, vol. 9,  no. 1, pp. 6-10, 2022. Crossref, https://doi.org/10.14445/23942592/IJPTE-V9I1P102

Abstract:

N, N, N-trimethyl chitosan chloride (TMCC) was synthesized by reductive methylation of Chitosan (DD 90% and mesh size 100) using iodomethane in the presence of sodium hydroxide. The wet chemical method synthesized zinc oxide nanoparticles (ZnO NPs). TMC particles and ZnO NPs were characterized by FTIR spectroscopy and scanning electron microscopy (SEM). TMC and ZnO-nanoparticle were suspended in water at room temperature in powder form and sonicated in the solution for 10 min. A UV-vis spectroscopy characterized the product. Quaternary chitosan-based ZnO nanocomposites have antimicrobial activities against Staphylococcus aureus and Escherichia coli. Bacteriological tests such as minimum inhibitory concentration (MIC) and disk diffusion method were performed in nutrient agar media. TMC exhibited improved water solubility and stronger anti-bacterial activity relative to Chitosan (CS) over an entire range of pH values. Modifying cotton fabric using quaternary Chitosan and ZnO nanoparticles-based composites increased antimicrobial properties. As the finished product is bio-derived, the product is biodegradable, biocompatible, non-toxic, and have good prospect in wound healing applications in the medical and healthcare sectors.

Keywords:

Chitosan, ZnO nanoparticles, Antimicrobial activity, Cotton fabric, Chitosan derivatives.

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