Optimized Machine Learning for CHD Detection using 3D CNN-based Segmentation, Transfer Learning and Adagrad Optimization

International Journal of Electrical and Electronics Engineering
© 2023 by SSRG - IJEEE Journal
Volume 10 Issue 3
Year of Publication : 2023
Authors : R. Selvaraj, T. Satheesh, V. Suresh, V. Yathavaraj
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How to Cite?

R. Selvaraj, T. Satheesh, V. Suresh, V. Yathavaraj, "Optimized Machine Learning for CHD Detection using 3D CNN-based Segmentation, Transfer Learning and Adagrad Optimization," SSRG International Journal of Electrical and Electronics Engineering, vol. 10,  no. 3, pp. 20-34, 2023. Crossref, https://doi.org/10.14445/23488379/IJEEE-V10I3P103

Abstract:

Globally, Coronary Heart Disease (CHD) is one of the main causes of death. Early detection of CHD can improve patient outcomes and reduce mortality rates. We propose a novel framework for predicting the presence of CHD using a combination of machine learning and image processing techniques. The framework comprises various phases, including analyzing the data, feature selection using ReliefF, 3D CNN-based segmentation, feature extraction by means of transfer learning, feature fusion as well as classification, and Adagrad optimization. The first step of the proposed framework involves analyzing the data to identify patterns and correlations that may be indicative of CHD. Next, ReliefF feature selection is applied to decide on the most relevant features from the sample images. The 3D CNN-based segmentation technique is then used to segment the optic disc and macula, which are important regions for CHD diagnosis. Feature extraction using transfer learning is performed to extract features from the segmented regions of interest. The extracted features are then fused using a feature fusion technique, and a classifier is trained to predict the presence of CHD. Finally, Adagrad optimization is used to optimize the performance of the classifier. Our framework is evaluated on a dataset of sample images collected from patients with and without CHD. The results show that the anticipated framework accomplishes elevated accuracy in predicting the presence of CHD. For the purpose of predicting as well as categorizing the patient with heart disease, we applied various ML classifier algorithms. By using Random Forest, Multilayer Perception, and Gradient Boosted Tree, the suggested model's intensity was quite exciting. Also, it was capable of forecasting symptoms associated with cardiovascular disease in either a particular user with a reasonable degree of accuracy compared to the previously employed classifiers like SVM, etc.

Keywords:

Coronary heart disease, Machine learning, Feature selection, Optimization, Segmentation, Classifier.

References:

[1] R. Alizadehsani et al., “Coronary Artery Disease Detection using Deep Learning Methods,” Procedia Computer Science, vol. 98, pp. 360-365, 2016. 
[2] Zachi I. Attia et al., “Prospective Validation of a Deep Learning Electrocardiogram Algorithm for the Detection of Left Ventricular Systolic Dysfunction,” Journal of Cardiovascular Electrophysiology, vol. 30, no. 5, pp. 668-674, 2019.
CrossRef | Google Scholar | Publisher Link
[3] K. Sudharson et al., “Hybrid Deep Learning Neural System for Brain Tumor Detection,” 2022 2nd International Conference on Intelligent Technologies (CONIT), pp. 1-6, 2022.
CrossRef | Google Scholar | Publisher Link
[4] L. Srinivasan et al., “IoT-Based Solution for Paraplegic Sufferer to Send Signals to Physician via Internet,” SSRG International Journal of Electrical and Electronics Engineering, vol. 10, no. 1, pp. 41-52, 2023.
CrossRef | Publisher Link
[5] Kwon JM, Lee YJ, and JS. Kim, “Machine Learning-based Prediction of Myocardial Infarction Using Big Data: A Nationwide Cohort Study,” BMC Cardiovascular Disorders, vol. 20, no. 1, 2020. 
[6] X. Xie et al., “Automatic Detection of Coronary Artery Disease using a Deep Convolutional Neural Network with Noise Reduction and Bayesian Optimization,” Medical Image Analysis, vol. 60, p. 101610, 2020. 
[7] P.R. Gajjala et al., “An Exploratory Analysis of Risk Factors for Coronary Heart Disease Using Logistic Regression Modeling,”  Clinical Medicine & Research, vol. 9, no. 2, pp. 107– 113, 2017. 
[8] Lu W, and K. Reshma, “Application of Logistic Regression Analysis in Predicting Coronary Heart Disease,” Journal of Taibah University Medical Science, vol. 15, no. 4, pp. 289-295, 2020. 
[9] X. Chen et al., “Decision Trees for Predicting Coronary Heart Disease Based on Genetic and Clinical Data,” BMC Medical Genetics, vol. 19, no. 1, pp. 1-13, 2018. 
[10] J. Wu et al., “Prediction of Coronary Heart Disease Risk Based on SVM,” International Journal of Clinical and Experimental Medicine, vol. 13, no. 10, pp. 8038-8045, 2020. 
[11] N. Garg, D. Gupta, and A. Yadav, “Convolutional Neural Network for Detection of Coronary Artery Disease using Myocardial Perfusion Scintigraphy,” Computers in Biology and Medicine, vol. 98, pp. 8-15, 2018. 
[12] S. Pujari, P. Rao, and S. Allamsetty, “Deep Neural Networks for Predicting the Risk of Heart Diseases,” International Journal of Advanced Computer Science Applications, vol. 12, no. 2, pp. 361-368, 2021. 
[13] J. Huang et al., “An Ensemble of Logistic Regression Model to Predict Coronary Artery Disease for a Chinese Population,” Computational and Mathematical Methods in Medicine, p. 2381843, 2019.  
[14] A. Hernáez et al., “Meta-analysis of Randomized Controlled Trials: Efficacy and Safety of Vitamin D Supplementation in Relation to HbA1c Concentrations in Prediabetes and Diabetes,” Nutrition, Metabolism and Cardiovascular Diseases,  vol. 31, no. 2, pp. 325-335, 2021. 
[15] X. Xu et al., “Diagnostic Accuracy of Serum Matrix Metalloproteinase-9 for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis,” European Review for Medical and Pharmacological Sciences, vol. 24, no. 18, pp. 9662-9672, 2020. 
[16] Pia R. Kamstrup, and Borge G. Nordestgaard, “Elevated Lipoprotein(a) Levels, LPA Risk Genotypes, and Increased  Risk of Heart Failure in the General Population,” Journal of the American College of Cardiology: Heart Failure, vol. 4, no. 1, pp. 78-87, 2016.
CrossRef | Google Scholar | Publisher Link
[17] B.B. Walker et al., “Spatial Association Between County-level Breast Cancer Mortality Rates and Timber Harvests, Pesticide Applications and Hazardous Waste Sites in California,” Spatial and Spatio-temporal Epidemiology, vol. 27, pp. 67-77, 2018. 
[18] Joann E. Manson et al., “Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease,” The New England Journal of Medicine, vol. 380, no. 1, pp. 33-44, 2019.
CrossRef | Google Scholar | Publisher Link
[19] Amit V. Khera et al., “Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease,” The New England Journal of Medicine, vol. 375, pp. 2349-2358, 2016.
CrossRef | Google Scholar | Publisher Link
[20] V.E. Hjortdal et al., “Risk of Infective Endocarditis in Patients with Bicuspid Aortic Valve: A Population-Based Cohort Study,” The American Journal of Medicine, vol. 130, no. 2, 2017. 
[21] S.A.H. Rizvi et al., “A Systematic Review of the Efficacy and Safety of Statins in the Pediatric Population,” American Journal of Cardiovascular Drugs, vol. 20, no. 5, pp. 399-406, 2020. 
[22] Y. Guo et al., “Effect of Omega-3 Carboxylic Acids on Lipoprotein-associated Phospholipase A2 and Cardiovascular Events in Patients with Elevated Triglyceride Levels: A Meta-analysis of Randomized Controlled Trials,” Clinical Nutrition, vol. 38, no. 4, pp. 1634-1641, 2019. 
[23] Y. Liu et al., “Relationship between Serum Vitamin D Level and Breast Cancer: A Meta-analysis of Observational Studies,” The Journal of Clinical Endocrinology & Metabolism, vol. 103, no. 7, pp. 2970-2979, 2018. 
[24] Williams Bryan et al., “2018 ESC/ESH Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Cardiology and the European Society of Hypertension.,” Journal of Hypertension, vol. 36, no. 10, pp. 1953-2041. 2018.
CrossRef | Publisher Link
[25] P. Bharadwaj et al., “Adherence to Mediterranean diet and risk of Stroke: A Systematic Review and a Meta-Analysis of Observational Studies,” Clinical Nutrition ESPEN, vol. 15, pp. 47-57, 2016. 
[26] D. Selvaraj et al., “Outsourced Analysis of Encrypted Graphs in the Cloud with Privacy Protection,” SSRG International Journal of Electrical and Electronics Engineering, vol. 10, no. 1, pp. 53-62, 2023.
CrossRef | Publisher Link
[27] P Joe Prathap et al., “Mining Privacy-Preserving Association Rules based on Parallel Processing in Cloud Computing,” International Journal of Engineering Trends and Technology, vol. 70, no. 3, pp. 284-294, 2022.
CrossRef | Publisher Link
[28] M Balachandran et al., “Predictive Analytics in Coronary Artery Disease - A Systematic Review,” Computer Methods and Programs in Biomedicine, vol. 208, pp. 106237, 2021. 
[29] S.M. Udhaya Sankar et al., “Safe Routing Approach by Identifying and Subsequently Eliminating the Attacks in MANET,” International Journal of Engineering Trends and Technology, vol. 70, no. 11, pp. 219-231, 2022.
CrossRef | Publisher Link
[30] SC Chien et al., “Prediction of Coronary Artery Disease Using Machine Learning: An Experience of Integrating Electronic Medical Claims and Clinical Data,” PLoS One, vol. 16, no. 2, 2021.
[31] Jena Catherine Bel D et al., “Trustworthy Cloud Storage Data Protection based on Blockchain Technology,” International Conference on Edge Computing and Applications (ICECAA), pp. 538-543, 2022.  
CrossRef | Google Scholar | Publisher Link
[32] Shakti Chourasiya, and Suvrat Jain, “A Study Review on Supervised Machine Learning Algorithms,” SSRG International Journal of Computer Science and Engineering, vol. 6,  no. 8, pp. 16-20, 2019.
CrossRef | Publisher Link
[33] G. Gomathy, “Automatic Waste Management based on IoT using a Wireless Sensor Network,” International Conference on Edge Computing and Applications (ICECAA), pp. 629-634, 2022.  
CrossRef | Google Scholar | Publisher Link
[34] He B et al., “A Machine Learning Approach for the Diagnosis of Coronary Artery Disease Based on Clinical Data,” Journal of Biomedical Informatics, vol. 81, pp. 202-207, 2018. 
[35] G. R. Meghana, Suresh Kumar Rudrahithlu, and K. C. Shilpa, “Detection of Brain Cancer using Machine Learning Techniques a Review,” SSRG International Journal of Computer Science and Engineering , vol. 9,  no. 9, pp. 12-18, 2022.  
CrossRef | Publisher Link
[36] D. Dhinakaran, and P. M. Joe Prathap, “Preserving Data Confidentiality in Association Rule Mining Using Data Share Allocator Algorithm,” Intelligent Automation & Soft Computing, vol. 33, no.3, pp. 1877–1892, 2022.
CrossRef | Google Scholar | Publisher Link
[37] N Khalifa et al., “A Hybrid Deep Learning Approach for Coronary Artery Disease Diagnosis,” Journal of Biomedical Informatics, vol. 109, pp. 103547, 2020.
[38] D. Dhinakaran et al., “Secure Android Location Tracking Application with Privacy Enhanced Technique,” Fifth International Conference on Computational Intelligence and Communication Technologies (CCICT), pp. 223-229, 2022.
CrossRef | Google Scholar | Publisher Link
[39] S. Farjana Farvin, and S. Krishna Mohan, “A Comparative Study on Lung Cancer Detection using Deep Learning Algorithms,” SSRG International Journal of Computer Science and Engineering , vol. 9,  no. 5, pp. 1-4, 2022.
CrossRef | Publisher Link
[40] J. Aruna Jasmine et al., “A Traceability set up using Digitalization of Data and Accessibility,” International Conference on Intelligent Sustainable Systems (ICISS), pp. 907-910, 2021.
CrossRef | Google Scholar | Publisher Link
[41] R. Tamilaruvi et al., “Brain Tumor Detection in MRI Images using Convolutional Neural Network Technique,”  SSRG International Journal of Electrical and Electronics Engineering, vol. 9,  no. 12, pp. 198-208, 2022.  
CrossRef | Publisher Link
[42] D. Dhinakaran et al., “Recommendation System for Research Studies Based on GCR,” International Mobile and Embedded Technology Conference (MECON), pp. 61-65, 2022.
CrossRef | Google Scholar | Publisher Link
[43] MY Rashwan et al., “Coronary Artery Disease Diagnosis Using Machine Learning Algorithms: A Review,” Journal of Medical Systems, vol. 41, no. 9, pp. 139, 2017. 
[44] D. Dhinakaran, and P. M. Joe Prathap, “Ensuring Privacy of Data and Mined Results of Data Possessor in Collaborative ARM," Pervasive Computing and Social Networking, Lecture Notes in Networks and Systems, vol. 317, pp. 431–444, 2022.
CrossRef | Google Scholar | Publisher Link
[45] S. Rajeswari et al., “Aspect Based Polarity Extraction in Tamil Tweets using Tree-Based Recursive Partitioning Techniques,” International Journal of Engineering Trends and Technology, vol. 70, no. 12, pp. 421-430, 2022.
CrossRef | Publisher Link
[46] L Yan et al., “Early Detection and Classification of Coronary Artery Disease using Machine Learning Techniques,” Journal of Healthcare Engineering, vol. 2018, pp. 2581023, 2018. 
[47] Dhinakaran D, and Joe Prathap P. M, “Protection of Data Privacy From Vulnerability using Two-Fish Technique with Apriori Algorithm in Data Mining,” The Journal of Supercomputing, vol. 78, no. 16, pp. 17559–17593, 2022.
CrossRef | Google Scholar | Publisher Link
[48] D Dhinakaran et al., “Assistive System for the Blind with Voice Output Based on Optical Character Recognition,” International Conference on Innovative Computing and Communications,  Lecture Notes in Networks and Systems, vol. 492, pp. 1-8, 2022.
CrossRef | Google Scholar | Publisher Link
[49] H Ghafoori et al., “Prediction of Coronary Artery Disease using a Machine Learning Approach Based on Feature Selection of Echocardiographic Variables,” Journal of Medical Systems, vol. 43, no. 6, pp. 139, 2019.
[50] W He et al., “Prediction of Coronary Artery Disease using a Combination of Convolutional Neural Networks and Long Short-Term Memory with Comprehensive Features from Electronic Health Records,” Journal of Medical Systems, vol. 45, no. 2, pp. 19, 2021.